Hepatobiliary & pancreatic diseases international, 2015-12, Vol.14 (6), p.619-625
2015
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Ankaflavin ameliorates steatotic liver ischemia- reperfusion injury in mice
- Ist Teil von
- Hepatobiliary & pancreatic diseases international, 2015-12, Vol.14 (6), p.619-625
- Ort / Verlag
- Singapore: Elsevier B.V
- Erscheinungsjahr
- 2015
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- BACKGROUND： It is well-known that steatotic liver is more susceptible to ischemia-reperfusion （I/R） injury during liver transplantation, liver resection and other liver surgeries. The increasing incidence of non-alcoholic fatty liver disease （NAFLD） decreases the availability of liver donors. Although steatotic liver is now accepted as a source of liver for trans- plantation, NAFLD exacerbates the liver injury after liver surgery. The present study was to investigate the protective role of ankaflavin in steatotic liver I/R injury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1499-3872DOI: 10.1016/S1499-3872(15)60361-7Titel-ID: cdi_wanfang_journals_gjgdybzz_z201506008
- Format
- –
- Schlagworte
- Animals, ankaflavin, Anti-Inflammatory Agents - pharmacology, Antioxidants - pharmacology, Apoptosis - drug effects, Biomarkers - blood, Cell Proliferation - drug effects, Cytokines - metabolism, Cytoprotection, Disease Models, Animal, Endocrinology & Metabolism, Flavins - pharmacology, Gastroenterology and Hepatology, Hepatocytes - drug effects, Hepatocytes - metabolism, Hepatocytes - pathology, ischemia-reperfusion, Kupffer cells, Kupffer Cells - drug effects, Kupffer Cells - metabolism, Kupffer Cells - pathology, Liver - drug effects, Liver - metabolism, Liver - pathology, Liver - surgery, Male, Mice, Inbred C57BL, Non-alcoholic Fatty Liver Disease - blood, Non-alcoholic Fatty Liver Disease - complications, Non-alcoholic Fatty Liver Disease - drug therapy, Non-alcoholic Fatty Liver Disease - pathology, Oxidative Stress - drug effects, Reperfusion Injury - blood, Reperfusion Injury - etiology, Reperfusion Injury - pathology, Reperfusion Injury - prevention & control, steatotic liver, 保护作用, 小鼠, 缺血-再灌注, 缺血再灌注, 肝损伤, 肝移植, 脂肪肝, 酒精性