Details

Autor(en) / Beteiligte

• Wang, Yingchun
• Li, Xiuying
• Li, Yajun
• Pan, Yingming
• Cheng, Keguang
• Wang, Hengshan

Titel

Simultaneous Reduction of Aldehyde Group to Hydroxymethyl Group in Palladium-catalyzed Suzuki Cross-coupling Reaction

Ist Teil von

• Chemical research in Chinese universities, 2014-08, Vol.30 (4), p.614-618

Ort / Verlag

Heidelberg: Jilin University and The Editorial Department of Chemical Research in Chinese Universities

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The authors presented an efficient method for the palladium-catalyzed Suzuki cross-coupling reaction with the simultaneous reduction of the aldehyde to a hydroxymethyl group.This method allows halide substituted aryl aldehydes to readily react with arylboronic acids,producing polycyclic aromatic alcohols in moderate to good yields.The reaction was catalyzed by Pd（OAc）2（3％,molar fraction） at 150 ℃ in the presence of 6％（molar fraction）1,4-diazabicyclo[2.2.2]octane（DABCO） and 3 times the molecular weight of K2CO3 in the mixture solvent of N,N-dimethylformamide（DMF）/H2O [V（DMF）∶ V（H2O）=5∶1].