Chemical research in Chinese universities, 2009-11, Vol.25 (6), p.856-860
2009
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- Autor(en) / Beteiligte
- Titel
- Design and Synthesis of New Anti-AIDS Drugs—— Introducing an Immunomodulator into Delavirdine Derivative
- Ist Teil von
- Chemical research in Chinese universities, 2009-11, Vol.25 (6), p.856-860
- Ort / Verlag
- College of Life Science, Jilin University, Changchun 130021, P. R. China%School of Pharmacy, Jilin University, Changchun 130021, P. R. China%Affiliated Hospital, Changchun Chinese Medicine University, Changchun 130061, P. R. China%College of Life Science, Jilin University, Changchun 130021, P. R. China
- Erscheinungsjahr
- 2009
- Beschreibungen/Notizen
- In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of anti-AIDs drug（compounds 5 and 7） was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of IH NMR, 13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.