Chemical research in Chinese universities, 2008-09, Vol.24 (5), p.557-560
2008
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- Autor(en) / Beteiligte
- Titel
- Selective Reduction of 7-Demethylsinomenine
- Ist Teil von
- Chemical research in Chinese universities, 2008-09, Vol.24 (5), p.557-560
- Ort / Verlag
- Elsevier Ltd
- Erscheinungsjahr
- 2008
- Beschreibungen/Notizen
- Several borohydride reagents： sodium borohydride, sodium cyanoborohydride, soudium acetoxyborohydride and soudium triacetoxyborohydride were screened, respectively, for the reduction of 7-demethylsinomenine, which was an α,β-dicarbonyl compound derived from sinomenine. Highly regio-and stereo-selectivity was acquired when sodium cyanoborohydride or NaBH（OAc）3 was used. The product was structurally confirmed as 7R configuration by NMR, X-ray crystal diffraction analysis. Some preliminary discussion was also made on the mechanism of the selective reduction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1005-9040eISSN: 2210-3171DOI: 10.1016/S1005-9040(08)60117-8Titel-ID: cdi_wanfang_journals_gdxxhxyj200805008
- Format
- –
- Schlagworte
- 7-Demethylsinomenine, Borohydride reagents, Regioselective reduction, Stereoselective reduction, 化学实验, 技术分析, 硼氢化物, 立体选择性