Details

Autor(en) / Beteiligte

• ZHANG Da-tong TANG Li-da DUAN Gui-yun ZHAO Gui-long XU Wei-ren MENG Li-juan WANG Jian-wu

Titel

Synthesis, Resolution, and Enantiomeric Purity Assay of 2-n-Butylbutanedioic Acid 4-t-Butyl Esters

Ist Teil von

• Chemical research in Chinese universities, 2006-09, Vol.22 (5), p.584-588

Ort / Verlag

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China%The Pharmaceutical Research Institute of Tianjin, Tianjin 300193, P. R. China

Erscheinungsjahr

2006

Beschreibungen/Notizen

• Racemic 2-n-butylbutanedioic acid 4-t-butyl esters were synthesized from methyl hexanoate and t-butyl α-iodoacetate via alkylation and subsequently selective hydrolyzation. The （R）-and （S）-2-n-butylbutanedioic acid 4-t-butyl esters were obtained by the resolution of the above-mentioned racemic compounds with（S）-（ - ） or（R）-（ ＋ ）-α- methylbenzylamine, respectively. The e.e. values of the two optical active products were determined to be above 99% by HPLC after the formation of two pairs of diastereoisomers with（R）-（ ＋ ）-α-methylbenzylamine and（S）- phenylalanine methyl ester.