Details

Autor(en) / Beteiligte

• Guoiing Zhang Wanqing Xie （Co-first author） Chao Lin Zhaozhe Liu Long Xu Guanzhong Zhang Fang Guo Yaling Han Hongxin Zheng Xiaodong Xie

Titel

Neoadjuvant chemotherapy for triple-negative breast cancer： a meta-analysis with 7168 cases

Ist Teil von

• 中德临床肿瘤学杂志（英文版）, 2014 (2), p.58-62

Ort / Verlag

Department of 0ncology, The General Hospital of Shenyang Military Region, Shenyang 110840, China%Molecular Biology Laboratory of Traditional Chinese Medicine, The Basic Medical College of Liaoning University of Traditional Chinese Medicine, Shengyang 110032, China%Department of Gynaecology and 0bstetrics, Zhejiang Chinese Medical University Affiliated Hospital of Wenzhou Traditional Chinese Medicine, Wenzhou 325000, China%Cardiovascular Disease Institute, General Hospital of Shenyang Military Region, Shenyang 110840, China

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Objective： The pathological complete response （pCR） rates of neoadjuvant chemotherapy （NAC） in triple-nega- tive breast cancer （TNBC） was reported higher than that in non-TNBC but ranged from 12% to 48%. pCR was reported to be a predictor of long overall survival and exact pCR rate of NAC in TNBC would give us some hints on how to improve outcomes of TNBC patients. The meta-analysis was conducted to estimate the pCR rate of NAC for TNBC through contrasting the pCR rates of TNBC and non-TNBC tumors in NAC. Methods： Studies were selected from the PubMed database and Cochrane Collaboration Library. pCR rates were collected in groups of TNBC and non-TNBC tumors. Review Manager 4.2 was used to perform forest plots and funnel plots. Results： The analysis included 22 studies with 7168 patients, the aggregate pCR rate was 29.5% in TNBC group, which was 17.7% higher than non-TNBC. The summary relative risk （RR） for pCR rate of TNBC group with that of non-TNBC group was 2.55. No obvious statistical heterogeneity and publication bias was detected. Conclu- sion： This meta-analysis demonstrated that NAC showed a higher pCR rate in TNBC than non-TNBC.