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THE TRANSMEMBRANE SIGNAL TRANSDUCTION IN HEp-2 CELLS INDUCED BY BACTERIAL ADHERENCE
Ist Teil von
Chinese medical sciences journal, 2000-03, Vol.15 (1), p.20-23
Ort / Verlag
China: Department of Etiology and Department of Pharmacology%Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005
Erscheinungsjahr
2000
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
In order to understand the role of transmembrane signal transduction of host cells in the early steps of infection,the adherence of E. coli to HEp-2 cells and the change of activity of phospholipase C-γ (PLC-γ) induced by the adherence were investigated. The adherence of enteropathogenic E. coli (EPEC), strain E. 7, induced a significant increase of inositol-triphosphat (IP-3) level in HEp-2 cells. The adherence of the bacteria and the increase of IP-3 was kinetically correlated.Whereas the increase of IP3 level induced by the adherence of the control strain EPEC (H511), a non-piliated strain, was much meager than that by E7, a piliated strain. The results highlighted an important role of transmernbrane signals like IP-3 in the pathogenesis of EPEC.