Details

Autor(en) / Beteiligte

• LI, Xue Lian
• XIE, Na
• WANG, Song Wang
• WU, Qian Hong
• MA, Yan
• SHU, Wei
• CHEN, Hong Mei
• ZHANG, Li Qun
• WU, Xiao Guang
• MA, Li Ping
• CHE, Nan Ying
• GAO, Meng Qiu

Titel

Diagnostic Value of Cerebrospinal Fluid T-SPOT.TB for Tuberculousis Meningitis in China

Ist Teil von

• Biomedical and environmental sciences, 2017-09, Vol.30 (9), p.681-684

Ort / Verlag

China: Elsevier B.V

Erscheinungsjahr

2017

Quelle

Elsevier ScienceDirect

Beschreibungen/Notizen

• The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid（CSF） T‐SPOT.TB test for the diagnosis of TB meningitis（TBM）. A retrospective analysis of 96 patients with manifested meningitis was conducted; T‐SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value（PPV）, and negative predictive value（NPV）. A receiver operating characteristic（ROC） curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T‐SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients（54.2%） of the 96 enrolled patients. The area under the curve（AUC） was 0.910, and the sensitivities of CSF T‐SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T‐SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.