Details

Autor(en) / Beteiligte

• DONG, Yin Ping
• WANG, Wei
• JIANG, Tao
• XU, Jin
• HAN, Chun Hui
• YAN, Shao Fei
• Fanning, Séamus
• LI, Ying
• MA, Xiao Chen
• ZHANG, Di
• ZHAO, Yao
• ZENG, Biao
• LI, Feng Qin

Titel

Molecular and Epidemiological Characterization of Infant Botulism in Beijing, China

Ist Teil von

• Biomedical and environmental sciences, 2017-06, Vol.30 (6), p.460-464

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Laboratory-based pathogen isolation, identification, and toxicity determination were performed on samples from a suspected case of infant botulism. Mice injected with cultures generated from the enema sample and ingested Powered infant formula （PIF） presented typical signs of botulism. Antitoxins to polyvalent botulinum neurotoxins （BoNTs） and monovalent BoNT type B antitoxin had protective effects. Clostridium botulinum isolated from the enema and residual PIF samples were positive for type B toxin. Pulsed-field gel electrophoresis （PFGE） revealed that the two strains of C. botulinum isolated from the two samples produced indistinguishable pulsotypes. These findings confirmed this case of type B infant botulism associated with the ingestion of PIF contaminated bv type B C. botulinum spores.