Details

Autor(en) / Beteiligte

• LI, Tian Zhi
• YUAN, Ming
• CHEN, Zhen Hong
• GUO, Ying Hua
• KANG, Chun Yan
• WANG, Jing Yu
• LI, Zhi Li
• WANG, De Sheng
• WANG, Hui Juan
• YUAN, Min
• LIU, Chang Ting

Titel

Effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats

Ist Teil von

• Biomedical and environmental sciences, 2013-02, Vol.26 (2), p.118-127

Ort / Verlag

China: Elsevier B.V

Erscheinungsjahr

2013

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Objective To study the effect of Simulated Microgravity and its Associated Mechanism on Pulmonary Circulation in Rats. Methods Rat tail-suspension model was used to simulate the physiological effects of microgravity and changes in pulmonary blood vessel morphology, pulmonary arterial and venous blood pressure, pulmonary vascular resistance, pulmonary vasomotoricity, as well as the regulation of pulmonary circulation by cytokines produced and released by the lung of rats were measured. Results The walls of pulmonary blood vessels of rats were thickened, and the pulmonary artery was reconstructed with increased pulmonary vascular resistance. The pulmonary blood vessels of rats became more prone to dilation as contractions increased. Rat epithelial Adrenomedulin gene transcription and protein expression were upregulated. The level of basic fibroblast growth Factor of rat was also elevated. Conclusion Findings from the present study on rats revealed that the microgravity can affect pulmonary blood vessel structure, pulmonary arterial pressure, and pulmonary blood vessel self-regulation and cytokine production.