Details

Autor(en) / Beteiligte

• Xiang, Zi-Chun
• Jiang, Yan
• Guo, Shun-Xing

Titel

In Vitro Anti-HIV Activity of a Chinese Fungus Extract

Ist Teil von

• Biomedical and environmental sciences, 2006-06, Vol.19 (3), p.169-172

Ort / Verlag

China: Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100094, China%National Center for AIDS/STD Control and Prevention (NCAIDS),Chinese Center for Disease Control and Prevention, Beijing 100050, China

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective To investigate the inhibitory effect of the mycelium extract from a Chinese fungus （MI） on HIV-I and its mode of action. Methods Several in vitro methods including time of action, time of addition and PCR were used to test the mode of action of M 1. Results M 1 inhibited acute HIV infection in vitro and was effective when it was added 12 h after infection. PCR analysis of infected cells demonstrated that MI delayed the appearance of late product of reverse transcription and HIV was blocked before its RNA expression. Conclusion The target of M 1 is post-integration of proviral DNA.