Details

Autor(en) / Beteiligte

• Kleerebezem, Michiel
• Binda, Sylvie
• Bron, Peter A
• Gross, Gabriele
• Hill, Colin
• van Hylckama Vlieg, Johan ET
• Lebeer, Sarah
• Satokari, Reetta
• Ouwehand, Arthur C

Titel

Understanding mode of action can drive the translational pipeline towards more reliable health benefits for probiotics

Ist Teil von

• Current opinion in biotechnology, 2019-04, Vol.56, p.55-60

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •A translational pipeline connecting probiotic mechanism of action to corresponding health benefits can support the application of these health promoting bacteria.•Alleviation of lactose maldigestion symptoms by the β-galactosidase of yoghurt bacteria underpins the importance of a translation pipeline.•Incompletely defined core properties of probiotics probably explain their health effects in antibiotic associated diarrhoea and necrotizing enterocolitis.•Stratification and recognition of the subpopulation that is responsive to specific probiotics will facilitate the delivery of effective health benefits.•Understanding the mechanism of action of probiotics will enable the selection and manufacturing of more effective probiotic products. The different levels of knowledge described in a translational pipeline (the connection of molecular mechanisms with pre-clinical physiological and human health effects) are not complete for many probiotics. At present, we are not in a position to fully understand the mechanistic basis of many well established probiotic health benefits which, in turn, limits our ability to use mechanisms to predict which probiotics are likely to be effective in any given population. Here we suggest that this concept of a translation pipeline connecting mechanistic insights to probiotic efficacy can support the selection and production of improved probiotic products. Such a conceptual pipeline would also provide a framework for the design of clinical trials to convincingly demonstrate the benefit of probiotics to human health in well-defined subpopulations.