European journal of clinical nutrition, 2014-09, Vol.68 (9), p.973-979
2014
Details
- Autor(en) / Beteiligte
- Titel
- High dietary protein intake, reducing or eliciting insulin resistance?
- Ist Teil von
- European journal of clinical nutrition, 2014-09, Vol.68 (9), p.973-979
- Ort / Verlag
- Basingstoke: Nature Publishing Group
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dietary proteins have an insulinotropic effect and thus promote insulin secretion, which indeed leads to enhanced glucose clearance from the blood. In the long term, however, a high dietary protein intake is associated with an increased risk of type 2 diabetes. Moreover, branched-chain amino acids (BCAA), a prominent group of amino acids, were recently identified to be associated with diabetes. Observational data and intervention studies do not point in the same direction regarding the effect of protein intake on insulin sensitivity and diabetes risk. Therefore, the first aim of this review will be to discuss human studies addressing high dietary protein intake and insulin action, with special attention for BCAA. In the second part, we will highlight the (patho) physiological consequences of high-protein diets regarding insulin action, in particular the role of the mechanistic target of the rapamycin pathway.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0954-3007eISSN: 1476-5640DOI: 10.1038/ejcn.2014.123Titel-ID: cdi_wageningen_narcis_oai_library_wur_nl_wurpubs_455319
- Format
- –
- Schlagworte
- Amino acids, Amino Acids, Branched-Chain - metabolism, Animals, Biological and medical sciences, Blood Glucose - metabolism, blood-glucose control, body-composition, chain amino-acids, Chain branching, Diabetes, Diabetes mellitus, Diabetes mellitus (non-insulin dependent), Diabetes Mellitus, Type 2 - etiology, Diabetes Mellitus, Type 2 - metabolism, Diet, Dietary intake, Dietary Proteins - administration & dosage, Dietary Proteins - pharmacology, Feeding. Feeding behavior, Fundamental and applied biological sciences. Psychology, glycemic control, Health aspects, Health risks, High protein diet, Humans, Insulin, Insulin - blood, Insulin resistance, Insulin Resistance - physiology, Insulin secretion, Life Sciences, low-carbohydrate-diet, low-fat diets, mammalian target, Medical sciences, Metabolic diseases, metabolic risk-factors, Observations, Proteins, Proteins in human nutrition, Rapamycin, Risk factors, skeletal-muscle, TOR Serine-Threonine Kinases - metabolism, Type 2 diabetes, Vertebrates: anatomy and physiology, studies on body, several organs or systems, weight-loss diet