Details

Autor(en) / Beteiligte

• Huang, Yinhua
• Li, Yingrui
• Burt, David W
• Chen, Hualan
• Zhang, Yong
• Qian, Wubin
• Kim, Heebal
• Gan, Shangquan
• Zhao, Yiqiang
• Li, Jianwen
• Yi, Kang
• Feng, Huapeng
• Zhu, Pengyang
• Li, Bo
• Liu, Qiuyue
• Fairley, Suan
• Magor, Katharine E
• Du, Zhenlin
• Hu, Xiaoxiang
• Goodman, Laurie
• Tafer, Hakim
• Vignal, Alain
• Lee, Taeheon
• Kim, Kyu-Won
• Sheng, Zheya
• An, Yang
• Searle, Steve
• Herrero, Javier
• Groenen, Martien A M
• Crooijmans, Richard P M A
• Faraut, Thomas
• Cai, Qingle
• Webster, Robert G
• Aldridge, Jerry R
• Warren, Wesley C
• Bartschat, Sebastian
• Kehr, Stephanie
• Marz, Manja
• Stadler, Peter F
• Smith, Jacqueline
• Kraus, Robert H S
• Zhao, Yaofeng
• Ren, Liming
• Fei, Jing
• Morisson, Mireille
• Kaiser, Pete
• Griffin, Darren K
• Rao, Man
• Pitel, Frederique
• Wang, Jun
• Li, Ning

Titel

The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

Ist Teil von

• Nature genetics, 2013-07, Vol.45 (7), p.776-783

Ort / Verlag

United States: Nature Publishing Group

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its β-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.