Details

Autor(en) / Beteiligte

• Thompson, Corinne N
• Phan, My V T
• Hoang, Nguyen Van Minh
• Minh, Pham Van
• Vinh, Nguyen Thanh
• Thuy, Cao Thu
• Nga, Tran Thi Thu
• Rabaa, Maia A
• Duy, Pham Thanh
• Dung, Tran Thi Ngoc
• Phat, Voong Vinh
• Nga, Tran Vu Thieu
• Tu, Le Thi Phuong
• Tuyen, Ha Thanh
• Yoshihara, Keisuke
• Jenkins, Claire
• Duong, Vu Thuy
• Phuc, Hoang Le
• Tuyet, Pham Thi Ngoc
• Ngoc, Nguyen Minh
• Vinh, Ha
• Chinh, Nguyen Tran
• Thuong, Tang Chi
• Tuan, Ha Manh
• Hien, Tran Tinh
• Campbell, James I
• Chau, Nguyen Van Vinh
• Thwaites, Guy
• Baker, Stephen

Titel

A prospective multi-center observational study of children hospitalized with diarrhea in Ho Chi Minh City, Vietnam

Ist Teil von

• The American journal of tropical medicine and hygiene, 2015-05, Vol.92 (5), p.1045-1052

Ort / Verlag

United States: The American Society of Tropical Medicine and Hygiene

Erscheinungsjahr

2015

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• We performed a prospective multicenter study to address the lack of data on the etiology, clinical and demographic features of hospitalized pediatric diarrhea in Ho Chi Minh City (HCMC), Vietnam. Over 2,000 (1,419 symptomatic and 609 non-diarrheal control) children were enrolled in three hospitals over a 1-year period in 2009-2010. Aiming to detect a panel of pathogens, we identified a known diarrheal pathogen in stool samples from 1,067/1,419 (75.2%) children with diarrhea and from 81/609 (13.3%) children without diarrhea. Rotavirus predominated in the symptomatic children (664/1,419; 46.8%), followed by norovirus (293/1,419; 20.6%). The bacterial pathogens Salmonella, Campylobacter, and Shigella were cumulatively isolated from 204/1,419 (14.4%) diarrheal children and exhibited extensive antimicrobial resistance, most notably to fluoroquinolones and third-generation cephalosporins. We suggest renewed efforts in generation and implementation of policies to control the sale and prescription of antimicrobials to curb bacterial resistance and advise consideration of a subsidized rotavirus vaccination policy to limit the morbidity due to diarrheal disease in Vietnam.