Details

Autor(en) / Beteiligte

• Bilgir, Oktay
• Kebapcilar, Levent
• Bilgir, Ferda
• Bozkaya, Giray
• Yildiz, Yasar
• Pinar, Pelin
• Tastan, Ahmet

Titel

Decreased Serum Fetuin-A Levels are Associated with Coronary Artery Diseases

Ist Teil von

• Internal Medicine, 2010, Vol.49(13), pp.1281-1285

Ort / Verlag

Japan: The Japanese Society of Internal Medicine

Erscheinungsjahr

2010

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background To analyze Fetuin-A levels and soluble cellular adhesion molecules in patients with acute coronary syndrome. Methods and Results Serum Fetuin-A and intercellular adhesion molecule-1 (sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1) levels were examined in 127 patients who presented with chest pain. These patients were classified in three groups: stable angina (SA, n=51), myocardial infarction (MI, n=34) and non-cardiac group (n=42). Logarithmic transformations were made for Fetuin-A levels. Log-Fetuin-A levels were higher in non-cardiac subjects compared to MI and SA patients (p<0.05). Patients with SA showed lower levels than controls but higher levels as compared to MI patients. After controlling for age and gender, levels of sVCAM-1 and sICAM-1 in patients with coronary atherosclerosis were not different from those in non-cardiac subjects. Conclusion Serum levels of soluble VCAM-1, ICAM-1 were not related to coronary artery disease (CAD), but fetuin-A levels seems to be decreased in SA and MI patients. Low fetuin-A may play a role in the pathophysiology of CAD.