Details

Autor(en) / Beteiligte

• Hamano, Kimikazu
• Nishida, Masahiko
• Hirata, Ken
• Mikamo, Akihito
• Li, Tao-Sheng
• Harada, Masahiko
• Miura, Toshiro
• Matsuzaki, Masunori
• Esato, Kensuke

Titel

Local Implantation of Autologous Bone Marrow Cells for Therapeutic Angiogenesis in Patients With Ischemic Heart Disease: Clinical Trial and Preliminary Results

Ist Teil von

• JAPANESE CIRCULATION JOURNAL, 2001, Vol.65(9), pp.845-847

Ort / Verlag

Kyoto: The Japanese Circulation Society

Erscheinungsjahr

2001

Quelle

MEDLINE

Beschreibungen/Notizen

• A new therapy for severe ischemic heart disease has been developed; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells (BMC). After confirming that no detrimental changes were induced by this treatment in a canine heart model, a clinical trial was commenced in 1999. Thus far, 5 patients have been given this new treatment concomitant with coronary artery bypass grafting and all have been followed up for at least 1 year. Autologous BMC were implanted into the ungraftable area and postoperative cardiac scintigraphy showed specific improvement in coronary perfusion in 3 of the 5 patients. Postoperative chest radiography, electrocardiography, echocardiography and blood tests did not reveal any detrimental changes. In conclusion, this new therapy appears to be safe and could provide a treatment option for patients with otherwise untreatable ischemic heart disease. (Jpn Circ J 2001; 65: 845 - 847)