Details

Autor(en) / Beteiligte

• Yap, Timothy E
• Husein, Salman
• Miralles de Imperial-Ollero, Juan Antonio
• Colizzi, Benedetta
• Cordeiro, Maria Francesca
• Younis, Saad

Titel

The efficacy of dexamethasone implants following anti-VEGF failure for macular oedema in retinal vein occlusion

Ist Teil von

• European journal of ophthalmology, 2021-11, Vol.31 (6), p.3214-3222

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose: To investigate the efficacy of intravitreal dexamethasone implants (DEX) after anti-VEGF failure in retinal vein occlusion macular oedema. Methods: Retrospective cohort study of DEX implant (0.7 mg) given after anti-VEGF ‘failure’. Switch to DEX occurred if a ⩽ +5 ETDRS letter gain and ⩽20% reduction in central subfield thickness was present following ⩾6 consecutive anti-VEGF injections. The primary endpoint was VA change 30 days after DEX. Secondary outcomes were peak VA change, VA change at monthly timepoints, percentage achieving 15-letter gain, central subfield thickness (CST) and intraocular pressure (IOP). Results: Sixty-two injections in 62 patients associated with 26% central retinal vein occlusion (CRVO) and 74% branch retinal vein occlusion (BRVO) were eligible. There was a modest, significant improvement in mean VA change at 30 days compared to baseline (+6 letters, 95% CI +2.2 to +9.1 letters, p < 0.01). DEX implant significantly improved mean peak VA change compared to preceding anti-VEGF by +18.1 letters in CRVO (p = 0.002) and +13.2 letters in BRVO (p < 0.0001). IOP peaked between 30 and 60 days following injection, with 31% of CRVO and 11% of BRVO patients experiencing an IOP ⩾ 25 mmHg. Conclusion: DEX implant provides useful rescue therapy in cases of anti-VEGF ‘failure’ for macular oedema following retinal vein occlusion, resulting in improved functional outcomes at 30 days.