Details

Autor(en) / Beteiligte

• Pierson, Richard N
• Fishman, Jay A
• Lewis, Gregory D
• D’Alessandro, David A
• Connolly, Margaret R
• Burdorf, Lars
• Madsen, Joren C
• Azimzadeh, Agnes M

Titel

Progress Toward Cardiac Xenotransplantation

Ist Teil von

• Circulation (New York, N.Y.), 2020-10, Vol.142 (14), p.1389-1398

Ort / Verlag

United States: by the American College of Cardiology Foundation and the American Heart Association, Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Consistent survival of life-supporting pig heart xenograft recipients beyond 90 days was recently reported using genetically modified pigs and a clinically applicable drug treatment regimen. If this remarkable achievement proves reproducible, published benchmarks for clinical translation of cardiac xenografts appear to be within reach. Key mechanistic insights are summarized here that informed recent pig design and therapeutic choices, which together appear likely to enable early clinical translation.