Details

Autor(en) / Beteiligte

• Tan, W C
• Sin, D D
• Bourbeau, J
• Hernandez, P
• Chapman, K R
• Cowie, R
• FitzGerald, J M
• Marciniuk, D D
• Maltais, F
• Buist, A S
• Road, J
• Hogg, J C
• Kirby, M
• Coxson, H
• Hague, C
• Leipsic, J
• O'Donnell, D E
• Aaron, S D

Titel

Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study

Ist Teil von

• Thorax, 2015-09, Vol.70 (9), p.822-829

Ort / Verlag

England: BMJ Publishing Group LTD

Erscheinungsjahr

2015

Link zum Volltext

Quelle

BMJ Journals Archiv - DFG Nationallizenzen

Beschreibungen/Notizen

• BackgroundThere is limited data on the risk factors and phenotypical characteristics associated with spirometrically confirmed COPD in never-smokers in the general population.AimsTo compare the characteristics associated with COPD by gender and by severity of airway obstruction in never-smokers and in ever-smokers.MethodWe analysed the data from 5176 adults aged 40 years and older who participated in the initial cross-sectional phase of the population-based, prospective, multisite Canadian Cohort of Obstructive Lung Disease study. Never-smokers were defined as those with a lifetime exposure of <1/20 pack year. Logistic regressions were constructed to evaluate associations for ‘mild’ and ‘moderate-severe’ COPD defined by FEV1/FVC <5th centile (lower limits of normal). Analyses were performed using SAS V.9.1 (SAS Institute, Cary, North Carolina, USA).ResultsThe prevalence of COPD (FEV1/FVC<lower limits of normal) in never-smokers was 6.4%, constituting 27% of all COPD subjects. The common independent predictors of COPD in never-smokers and ever-smokers were older age, self reported asthma and lower education. In never-smokers a history of hospitalisation in childhood for respiratory illness was discriminative, while exposure to passive smoke and biomass fuel for heating were discriminative for women. COPD in never-smokers and ever-smokers was characterised by increased respiratory symptoms, ‘respiratory exacerbation’ events and increased residual volume/total lung capacity, but only smokers had reduced DLCO/Va and emphysema on chest CT scans.ConclusionsThe study confirmed the substantial burden of COPD among never-smokers, defined the common and gender-specific risk factors for COPD in never-smokers and provided early insight into potential phenotypical differences in COPD between lifelong never-smokers and ever-smokers.Trial registration numberNCT00920348 (ClinicalTrials.gov); study ID number: IRO-93326.