Science (American Association for the Advancement of Science), 2010-12, Vol.330 (6009), p.1344-1348
2010
Details
- Autor(en) / Beteiligte
- Titel
- Autophagy and Metabolism
- Ist Teil von
- Science (American Association for the Advancement of Science), 2010-12, Vol.330 (6009), p.1344-1348
- Ort / Verlag
- United States: American Association for the Advancement of Science
- Erscheinungsjahr
- 2010
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Autophagy is a process of self-cannibalization. Cells capture their own cytoplasm and organelles and consume them in lysosomes. The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes. Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1193497Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3010857
- Format
- –
- Schlagworte
- Amino acids, Animals, Autophagy, Cancer, Cell Survival, Cellular, Cellular metabolism, Construction, Consumption, Damage, Disease, Diseases, Energy Metabolism, Homeostasis, Humans, Lipid metabolism, Lipids, Liver, Metabolic diseases, Metabolism, Neoplasms - metabolism, Neoplasms - pathology, Nutrients, Phagosomes - metabolism, Preserves, Proteins - metabolism, REVIEWS, Signal Transduction, Starvation, TOR Serine-Threonine Kinases - metabolism, Tumors