Details

Autor(en) / Beteiligte

• Reiterer, Friedrich
• Scheuchenegger, Anna
• Resch, Bernhard
• Maurer‐Fellbaum, Ute
• Avian, Alexander
• Urlesberger, Berndt

Titel

Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Ist Teil von

• Pediatrics international, 2019-04, Vol.61 (4), p.381-387

Ort / Verlag

Australia: Blackwell Publishing Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long‐term outcome. Methods This was a retrospective, single‐center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24+0–28+6 weeks) with BPD (n = 44), with a cohort of GA‐matched preterm infants without BPD (n = 44) with regard to neonatal morbidity, incidence of lower respiratory tract infection (LRTI), ND outcome and growth to 2 years' corrected age (CA) and preschool age. Results Bronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of head circumference < 10th percentile was higher at preschool age (59% vs 27%, P = 0.028). Conclusion Neonatal respiratory morbidity was significantly higher in the BPD cohort, but long‐term ND outcome did not differ. Infants with BPD had poorer growth.