Details

Autor(en) / Beteiligte

• Frankenstein, Lutz
• Remppis, Andrew
• Nelles, Manfred
• Schaelling, Bernd
• Schellberg, Dieter
• Katus, Hugo
• Zugck, Christian

Titel

Relation of N-terminal pro-brain natriuretic peptide levels and their prognostic power in chronic stable heart failure to obesity status

Ist Teil von

• European heart journal, 2008-11, Vol.29 (21), p.2634-2640

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2008

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Aims To investigate the relationship between body mass index (BMI) and N-terminal pro-brain natriuretic peptide (NTproBNP) level and resultant prognostic capacity in chronic heart failure (CHF) controlled for known confounders. Methods and results We formed 206 triplets of patients (n = 618) with stable systolic CHF matched with respect to age, sex, renal function (MDRD, modification of diet in renal disease formula), and NYHA class, each with a BMI >30 kg/m2 (group 3), 20–24.9 kg/m2 (group 1), and 25–29.9 kg/m2 (group 2). BMI conveys a 4% drop in NTproBNP per unit increase. This influence remained significant after correction for age, sex, MDRD, NYHA, heart rate, rhythm, and ejection fraction. NTproBNP remained an independent predictor of adverse outcome after correction for age, sex, BMI, NYHA, MDRD, and ejection fraction. Despite numerical differences, prognostic power was comparable between BMI groups (log-transformed NTproBNP; group 1: hazard ratio (HR) 1.435, 95% CI 1.046–1.967, χ2 5.02, P = 0.03; group 2: HR 1.604, 95% CI 1.203–2.138, χ2 10.36, P = 0.001; group 3: HR 1.735, 95% CI 1.302–2.313, χ2 14.12, P = 0.0002) (P = NS, all). An NTproBNP correction factor was calculated. Conclusion Even matched for NYHA, age, sex, and renal function, BMI exerts a significant and independent inverse influence on NTproBNP in patients with stable CHF. NTproBNP retained equal statistical power in all three BMI groups.