Details

Autor(en) / Beteiligte

• Bogden, JD
• Bendich, A
• Kemp, FW
• Bruening, KS
• Shurnick, JH
• Denny, T
• Baker, H
• Louria, DB

Titel

Daily micronutrient supplements enhance delayed-hypersensitivity skin test responses in older people

Ist Teil von

• The American journal of clinical nutrition, 1994-09, Vol.60 (3), p.437-447

Ort / Verlag

Bethesda, MD: Elsevier Inc

Erscheinungsjahr

1994

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A placebo-controlled double-blind trial of the effects of daily micronutrient supplements on circulating vitamin and trace metal concentrations and delayed-hypersensitivity skin test (DHST) responses was conducted. Subjects, aged 59–85 y, were randomly assigned to placebo (n = 27) or micronutrient (n = 29) treatment groups. DHST and circulating concentrations of nine micronutrients were measured before and after 6 and 12 mo of micronutrient ingestion. For the micronutrient group, there were statistically significant increases at 6 and/or 12 mo in the mean serum concentrations of ascorbate, β-carotene, folate, vitamin B-6, and α-tocopherol. There was a significant increase at 12 mo in the number of subjects in the placebo group with one or more low concentrations. DHST responses to a panel of seven recall antigens were significantly increased at 12 mo in the micronutrient group but not the placebo group. This study demonstrates that daily supplementation with low-to-moderate doses of micronutrients can prevent low concentrations of some micronutrients and can improve DHST responses in healthy, independently living older adults.