Natural product research, 2020-10, Vol.34 (19), p.2816-2821
2020
Details
- Autor(en) / Beteiligte
- Titel
- Bioactive triterpenoids from Sambucus javanica Blume
- Ist Teil von
- Natural product research, 2020-10, Vol.34 (19), p.2816-2821
- Ort / Verlag
- England: Taylor & Francis
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupeol palmitate (7), respectively. Compounds 1 and 3 exhibited inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophage cell lines with IC 50 values of 17.4 and 26.2 μM, respectively.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1478-6419eISSN: 1478-6427DOI: 10.1080/14786419.2019.1596092Titel-ID: cdi_informaworld_taylorfrancis_310_1080_14786419_2019_1596092
- Format
- –
- Schlagworte
- Acids, Animals, Anti-Inflammatory Agents, Non-Steroidal - chemistry, Anti-Inflammatory Agents, Non-Steroidal - pharmacology, Cell lines, javablumine A, Lipopolysaccharides, Lipopolysaccharides - pharmacology, Macrophages, Mice, Molecular Structure, Nitric oxide, Nitric Oxide - metabolism, Oleanolic acid, Oleanolic Acid - analogs & derivatives, Oleanolic Acid - isolation & purification, Oleanolic Acid - pharmacology, Palmitic acid, Pentacyclic Triterpenes - isolation & purification, Pentacyclic Triterpenes - pharmacology, Plant Components, Aerial - chemistry, RAW 264.7 Cells, Sambucus, Sambucus - chemistry, Sambucus javanica Blume, triterpenes, Triterpenes - chemistry, Triterpenes - isolation & purification, Triterpenes - pharmacology, Triterpenoids, Ursolic Acid