Details

Autor(en) / Beteiligte

• Hart, Michael M.
• Adamson, Richard H.

Titel

Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1971-07, Vol.68 (7), p.1623-1626

Ort / Verlag

National Academy of Sciences of the United States of America

Erscheinungsjahr

1971

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The toxicity and antitumor activity of salts of the Group IIIa metals aluminum, gallium, indium, and thallium were determined. With the (lethal dose)50as a measure, the decreasing order of toxicity was TlCl3≥ In(NO3)3> Ga(NO3)3> Al(NO3)3. All four metals exhibited antitumor activity, but when the tumor was inoculated by a route different from that of the drug, only Ga+3and, to a lesser extent, ln+3inhibited tumor growth. Ga(NO3)3was found to inhibit the growth of three out of four rodent solid tumors. Gallium therefore has potential therapeutic usefulness for treatment of solid tumors in man.