Details

Autor(en) / Beteiligte

• Masujin, Kentaro
• Okada, Hiroyuki
• Miyazawa, Kohtaro
• Matsuura, Yuichi
• Imamura, Morikazu
• Iwamaru, Yoshifumi
• Murayama, Yuichi
• Yokoyama, Takashi

Titel

Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE

Ist Teil von

• Scientific reports, 2016-03, Vol.6 (1), p.22753-22753, Article 22753

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2016

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• The H-type of atypical bovine spongiform encephalopathy (H-BSE) was serially passaged in bovinized transgenic (TgBoPrP) mice. At the fourth passage, most challenged mice showed a typical H-BSE phenotype with incubation periods of 223 ± 7.8 days. However, a different phenotype of BSE prion with shorter incubation periods of 109 ± 4 days emerged in a minor subset of the inoculated mice. The latter showed distinct clinical signs, brain pathology, and abnormal prion protein profiles as compared to H-BSE and other known BSE strains in mice. This novel prion was transmitted intracerebrally to cattle, with incubation periods of 14.8 ± 1.5 months, with phenotypes that differed from those of other bovine prion strains. These data suggest that intraspecies transmission of H-BSE in cattle allows the emergence of a novel BSE strain. Therefore, the continuation of feed ban programs may be necessary to exclude the recycling of H-BSE prions, which appear to arise spontaneously, in livestock. Such measures should help to reduce the risks from both novel and known strains of BSE.