Details

Autor(en) / Beteiligte

• Yao, Xiao-Hong
• Luo, Tao
• Shi, Yu
• He, Zhi-Cheng
• Tang, Rui
• Zhang, Pei-Pei
• Cai, Jun
• Zhou, Xiang-Dong
• Jiang, Dong-Po
• Fei, Xiao-Chun
• Huang, Xue-Quan
• Zhao, Lei
• Zhang, Heng
• Wu, Hai-Bo
• Ren, Yong
• Liu, Zhen-Hua
• Zhang, Hua-Rong
• Chen, Cong
• Fu, Wen-Juan
• Li, Heng
• Xia, Xin-Yi
• Chen, Rong
• Wang, Yan
• Liu, Xin-Dong
• Yin, Chang-Lin
• Yan, Ze-Xuan
• Wang, Juan
• Jing, Rui
• Li, Tai-Sheng
• Li, Wei-Qin
• Wang, Chao-Fu
• Ding, Yan-Qing
• Mao, Qing
• Zhang, Ding-Yu
• Zhang, Shu-Yang
• Ping, Yi-Fang
• Bian, Xiu-Wu

Titel

A cohort autopsy study defines COVID-19 systemic pathogenesis

Ist Teil von

• Cell research, 2021-08, Vol.31 (8), p.836-846

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic dissemination remain largely unknown. We profiled 26 COVID-19 autopsy cases from four cohorts in Wuhan, China, and determined the systemic distribution of SARS-CoV-2. SARS-CoV-2 was detected in the lungs and multiple extrapulmonary organs of critically ill COVID-19 patients up to 67 days after symptom onset. Based on organotropism and pathological features of the patients, COVID-19 was divided into viral intrapulmonary and systemic subtypes. In patients with systemic viral distribution, SARS-CoV-2 was detected in monocytes, macrophages, and vascular endothelia at blood-air barrier, blood-testis barrier, and filtration barrier. Critically ill patients with long disease duration showed decreased pulmonary cell proliferation, reduced viral RNA, and marked fibrosis in the lungs. Permanent SARS-CoV-2 presence and tissue injuries in the lungs and extrapulmonary organs suggest direct viral invasion as a mechanism of pathogenicity in critically ill patients. SARS-CoV-2 may hijack monocytes, macrophages, and vascular endothelia at physiological barriers as the ports of entry for systemic dissemination. Our study thus delineates systemic pathological features of SARS-CoV-2 infection, which sheds light on the development of novel COVID-19 treatment.