Details

Autor(en) / Beteiligte

• Pardi, Norbert
• Hogan, Michael J
• Porter, Frederick W
• Weissman, Drew

Titel

mRNA vaccines - a new era in vaccinology

Ist Teil von

• Nature reviews. Drug discovery, 2018-04, Vol.17 (4), p.261-279

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2018

Link zum Volltext

Beschreibungen/Notizen

• mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans. This Review provides a detailed overview of mRNA vaccines and considers future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use.