Nature genetics, 2017-09, Vol.49 (9), p.1364-1372
2017
Details
- Autor(en) / Beteiligte
- Titel
- A gene encoding maize caffeoyl-CoA O-methyltransferase confers quantitative resistance to multiple pathogens
- Ist Teil von
- Nature genetics, 2017-09, Vol.49 (9), p.1364-1372
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Beschreibungen/Notizen
- Alleles that confer multiple disease resistance (MDR) are valuable in crop improvement, although the molecular mechanisms underlying their functions remain largely unknown. A quantitative trait locus, qMdr , associated with resistance to three important foliar maize diseases-southern leaf blight, gray leaf spot and northern leaf blight-has been identified on maize chromosome 9. Through fine-mapping, association analysis, expression analysis, insertional mutagenesis and transgenic validation, we demonstrate that ZmCCoAOMT2, which encodes a caffeoyl-CoA O-methyltransferase associated with the phenylpropanoid pathway and lignin production, is the gene within qMdr conferring quantitative resistance to both southern leaf blight and gray leaf spot. We suggest that resistance might be caused by allelic variation at the level of both gene expression and amino acid sequence, thus resulting in differences in levels of lignin and other metabolites of the phenylpropanoid pathway and regulation of programmed cell death.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.3919Titel-ID: cdi_proquest_journals_1938055928
- Format
- –
- Schlagworte
- Amino acid sequence, Apoptosis, Apoptosis - genetics, Association analysis, Blight, Caffeoyl-CoA O-methyltransferase, Cell death, Chromosome 9, Chromosome Mapping - methods, Corn, Crop diseases, Crop improvement, Crops, Disease resistance, Disease resistance (Plants), Disease Resistance - genetics, Diseases and pests, Gene expression, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Plant, Gene mapping, Genes, Plant - genetics, Genetic aspects, Genomes, Genotype & phenotype, Insertional mutagenesis, Kinases, Leaf blight, Leafspot, Leaves, Lignin, Lignin - metabolism, Metabolites, Methyltransferase, Methyltransferases, Methyltransferases - genetics, Methyltransferases - metabolism, Microscopy, Fluorescence, Molecular modelling, Mutagenesis, Mutation, Northern leaf blight, Phenylpropionates - metabolism, Physiological aspects, Plant diseases, Plant Diseases - genetics, Plant Diseases - microbiology, Plant immunology, Plant Leaves - genetics, Plant Leaves - metabolism, Plant Leaves - microbiology, Plants, Genetically Modified, Proteins, Quantitative trait loci, Quantitative Trait Loci - genetics, Reverse Transcriptase Polymerase Chain Reaction, Rice, Southern leaf blight, Studies, Wheat, Zea mays - genetics, Zea mays - metabolism, Zea mays - microbiology