Details

Autor(en) / Beteiligte

• Geurts, Lucie
• Everard, Amandine
• Van Hul, Matthias
• Essaghir, Ahmed
• Duparc, Thibaut
• Matamoros, Sébastien
• Plovier, Hubert
• Castel, Julien
• Denis, Raphael G P
• Bergiers, Marie
• Druart, Céline
• Alhouayek, Mireille
• Delzenne, Nathalie M
• Muccioli, Giulio G
• Demoulin, Jean-Baptiste
• Luquet, Serge
• Cani, Patrice D

Titel

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

Ist Teil von

• Nature communications, 2015-03, Vol.6 (1), p.6495-6495, Article 6495

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2015

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adipocytes induces obesity, glucose intolerance, adipose tissue inflammation and altered lipid metabolism. We report that Napepld-deleted mice present an altered browning programme and are less responsive to cold-induced browning, highlighting the essential role of NAPE-PLD in regulating energy homeostasis and metabolism in the physiological state. Our results indicate that these alterations are mediated by a shift in gut microbiota composition that can partially transfer the phenotype to germ-free mice. Together, our findings uncover a role of adipose tissue NAPE-PLD on whole-body metabolism and provide support for targeting NAPE-PLD-derived bioactive lipids to treat obesity and related metabolic disorders.