Details

Autor(en) / Beteiligte

• Baba, Takashi
• Otake, Hiroyuki
• Sato, Tetsuya
• Miyabayashi, Kanako
• Shishido, Yurina
• Wang, Chia-Yih
• Shima, Yuichi
• Kimura, Hiroshi
• Yagi, Mikako
• Ishihara, Yasuhiro
• Hino, Shinjiro
• Ogawa, Hidesato
• Nakao, Mitsuyoshi
• Yamazaki, Takeshi
• Kang, Dongchon
• Ohkawa, Yasuyuki
• Suyama, Mikita
• Chung, Bon-Chu
• Morohashi, Ken-Ichirou

Titel

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1

Ist Teil von

• Nature communications, 2014-04, Vol.5 (1), p.3634-3634, Article 3634

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Genetic deficiencies in transcription factors can lead to the loss of certain types of cells and tissue. The steroidogenic tissue-specific nuclear receptor Ad4BP/SF-1 (NR5A1) is one such gene, because mice in which this gene is disrupted fail to develop the adrenal gland and gonads. However, the specific role of Ad4BP/SF-1 in these biological events remains unclear. Here we use chromatin immunoprecipitation sequencing to show that nearly all genes in the glycolytic pathway are regulated by Ad4BP/SF-1. Suppression of Ad4BP/SF-1 by small interfering RNA reduces production of the energy carriers ATP and nicotinamide adenine dinucleotide phosphate, as well as lowers expression of genes involved in glucose metabolism. Together, these observations may explain tissue dysgenesis as a result of Ad4BP/SF-1 gene disruption in vivo. Considering the function of estrogen-related receptor α, the present study raises the possibility that certain types of nuclear receptors regulate sets of genes involved in metabolic pathways to generate energy carriers.