Details

Autor(en) / Beteiligte

• Li, Shanshan
• Xie, Qingfeng
• Zeng, Yuqun
• Zou, Chuan
• Liu, Xusheng
• Wu, Shouhai
• Deng, Haixia
• Xu, Yang
• Li, Xian C
• Dai, Zhenhua

Titel

A naturally occurring CD8^＋CD122^＋ T-cell subset as a memory-like Treg family

Ist Teil von

• Cellular & molecular immunology, 2014-07, Vol.11 (4), p.326-331

Ort / Verlag

China: Nature Publishing Group

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Despite extensive studies on CD4^＋CD25^＋ regulatory T cells （Tregs） during the past decade, the progress on their clinical translation remains stagnant. Mounting evidence suggests that naturally occurring CD8^＋CD122^＋ T cells are also Tregs with the capacity to inhibit T-cell responses and suppress autoimmunity as well as alloimmunity. In fact, they are memory-like Tregs that resemble a central memory T cell （TcM） phenotype. The mechanisms underlying their suppression are still not well understood, although they may include IL-IO production. We have recently demonstrated that programmed death-1 （PD-1） expression distinguishes between regulatory and memory CD8^＋CD122^＋ T cells and that CD8^＋CD122^＋ Tregs undergo faster homeostatic proliferation and are more potent in the suppression of allograft rejection than conventional CD4^＋CD25^＋ Tregs. These findings may open a new line of investigation for accelerating effective Treg therapies in the clinic. In this review, we summarize the significant progress in this promising field of CD8^＋CD122^＋ Treg research and discuss their phenotypes, suppressive roles in autoimmunity and alloimmunity, functional requirements, mechanisms of action and potential applications in the clinic.