Frontiers in neuroendocrinology, 2019-10, Vol.55, p.100793-100793, Article 100793
2019
Details
- Autor(en) / Beteiligte
- Titel
- Lifelong consequences of brain injuries during development: From risk to resilience
- Ist Teil von
- Frontiers in neuroendocrinology, 2019-10, Vol.55, p.100793-100793, Article 100793
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- •Outcomes from pediatric TBI are highly heterogeneous.•TBI-induced disruption of neuroendocrine development impairs psychosocial recovery.•Persistent dysregulation of autonomic physiology may predict long-term outcome.•The development of PTSS is associated with impaired pediatric TBI recovery. Traumatic brain injuries in children represent a major public health issue and even relatively mild injuries can have lifelong consequences. However, the outcomes from these injuries are highly heterogeneous, with most individuals recovering fully, but a substantial subset experiencing prolonged or permanent disabilities across a number of domains. Moreover, brain injuries predispose individuals to other kinds of neuropsychiatric and somatic illnesses. Critically, the severity of the injury only partially predicts subsequent outcomes, thus other factors must be involved. In this review, we discuss the psychological, social, neuroendocrine, and autonomic processes that are disrupted following traumatic brain injury during development, and consider the mechanisms the mediate risk or resilience after traumatic brain injury in this vulnerable population.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0091-3022eISSN: 1095-6808DOI: 10.1016/j.yfrne.2019.100793Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6905510
- Format
- –
- Schlagworte
- Autonomic, Autonomic Nervous System - metabolism, Autonomic Nervous System - physiopathology, Behavioral Symptoms - etiology, Behavioral Symptoms - metabolism, Behavioral Symptoms - physiopathology, Brain Injuries, Traumatic - complications, Brain Injuries, Traumatic - metabolism, Brain Injuries, Traumatic - physiopathology, Growth Hormone - deficiency, HPA axis, Human Development - physiology, Humans, Hypothalamo-Hypophyseal System - metabolism, Hypothalamo-Hypophyseal System - physiopathology, Neurosecretory Systems - metabolism, Neurosecretory Systems - physiopathology, Pituitary dysfunction, Resilience, Risk, Social Behavior Disorders - etiology, Social Behavior Disorders - metabolism, Social Behavior Disorders - physiopathology, Stress, Stress Disorders, Post-Traumatic - etiology, Stress Disorders, Post-Traumatic - metabolism, Stress Disorders, Post-Traumatic - physiopathology, Traumatic brain injury