Details
- Autor(en) / Beteiligte
- Titel
- The Na+ /HCO3− co-transporter is protective during ischemia in astrocytes
- Ist Teil von
- Neuroscience, 2016-12, Vol.339, p.329-337
- Ort / Verlag
- Elsevier Ltd
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- Highlights • Generation of astrocytes from human-induced pluripotent stem cells (hiPSCs). • Functional sodium bicarbonate co-transporters (NBCs) exist in hiPSC-derived astrocytes. • Gene expression of electrogenic sodium bicarbonate co-transporter is enhanced under ischemia. • An NBC inhibitor exaggerates Ischemia-induced cell death in hiPSC-derived astrocytes.