Details

Autor(en) / Beteiligte

• Norton, Thomas T.
• Siegwart, John T.

Titel

Light levels, refractive development, and myopia – A speculative review

Ist Teil von

• Experimental eye research, 2013-09, Vol.114, p.48-57

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2013

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Recent epidemiological evidence in children indicates that time spent outdoors is protective against myopia. Studies in animal models (chick, macaque, tree shrew) have found that light levels (similar to being in the shade outdoors) that are mildly elevated compared to indoor levels, slow form-deprivation myopia and (in chick and tree shrew) lens-induced myopia. Normal chicks raised in low light levels (50 lux) with a circadian light on/off cycle often develop spontaneous myopia. We propose a model in which the ambient illuminance levels produce a continuum of effects on normal refractive development and the response to myopiagenic stimuli such that low light levels favor myopia development and elevated levels are protective. Among possible mechanisms, elevation of retinal dopamine activity seems the most likely. Inputs from intrinsically-photosensitive retinal ganglion cells (ipRGCs) at elevated light levels may be involved, providing additional activation of retinal dopaminergic pathways. •Reviews effects of outdoor light levels on human refractive development and myopia.•Reviews effects of light levels on animal models of refractive development.•Examines possible mechanisms for the effect of illuminance on refraction.•Proposes a model of how elevated illuminance may act via dopaminergic pathways.