European journal of medicinal chemistry, 2019-12, Vol.183, p.111704-111704, Article 111704
2019
Details
- Autor(en) / Beteiligte
- Titel
- Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
- Ist Teil von
- European journal of medicinal chemistry, 2019-12, Vol.183, p.111704-111704, Article 111704
- Ort / Verlag
- France: Elsevier Masson SAS
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. [Display omitted] •Synthesis of asymmetric curcumin derivatives and their biological activities.•Asymmetric curcumin derivatives showed vast potential against cancer and inflammation.•The use of asymmetric curcumin derivatives as molecular probes and adjuvants.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0223-5234eISSN: 1768-3254DOI: 10.1016/j.ejmech.2019.111704Titel-ID: cdi_proquest_miscellaneous_2299143338
- Format
- –
- Schlagworte
- Acute Lung Injury - drug therapy, Animals, Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis, Anti-Inflammatory Agents, Non-Steroidal - chemistry, Anti-Inflammatory Agents, Non-Steroidal - pharmacology, Antineoplastic Agents - chemical synthesis, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, Asymmetric curcumin, Bioactivity, Carbonic Anhydrase Inhibitors - chemical synthesis, Carbonic Anhydrase Inhibitors - chemistry, Carbonic Anhydrase Inhibitors - pharmacology, Carbonic Anhydrases - metabolism, Curcumin - chemical synthesis, Curcumin - chemistry, Curcumin - pharmacology, Diketone, Humans, Molecular Structure, Monoketone, Neoplasms - drug therapy, Synthesis