Atherosclerosis, 2012-06, Vol.222 (2), p.360-366
2012
Details
- Autor(en) / Beteiligte
- Titel
- Inhibition of hepatic scavenger receptor-class B type I by RNA interference decreases atherosclerosis in rabbits
- Ist Teil von
- Atherosclerosis, 2012-06, Vol.222 (2), p.360-366
- Ort / Verlag
- Amsterdam: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2012
- Link zum Volltext
- Quelle
- Elsevier ScienceDirect Journals Complete
- Beschreibungen/Notizen
- Highlights ► Small hairpin RNA specific for SR-BI nucleotides 214-232 reduces SR-BI expression in vitro. ► SiRNA treatment reduces liver expression of SR-BI in New Zealand White rabbits. ► Liver specific inhibition of SR-BI leads to a 50% reduction of atherosclerosis in cholesterol fed rabbits. ► The role of SR-BI in rabbits may be different from the one found in rodents.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9150eISSN: 1879-1484DOI: 10.1016/j.atherosclerosis.2012.03.012Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3405511
- Format
- –
- Schlagworte
- animal models, Animals, Apolipoprotein A-I - blood, Apolipoproteins B - blood, atherogenesis, atherosclerosis, Atherosclerosis (general aspects, experimental research), Atherosclerosis - blood, Atherosclerosis - genetics, Atherosclerosis - therapy, Biological and medical sciences, Biomarkers - blood, Blood and lymphatic vessels, Cardiology. Vascular system, Cardiovascular, CD36 Antigens - genetics, CD36 Antigens - metabolism, Cell Line, Tumor, Cholesterol Ester Transfer Proteins - metabolism, Cholesterol Esters - metabolism, Cholesterol, HDL - blood, Cholesterol, VLDL - blood, Cholesteryl ester transfer protein, Diabetes. Impaired glucose tolerance, diet, Disease Models, Animal, Endocrine pancreas. Apud cells (diseases), Endocrinopathies, Gene therapy, gene transfer, genes, Genetic Therapy - methods, HDL receptor, high density lipoprotein cholesterol, homeostasis, Humans, Hypercholesterolemia, Hypercholesterolemia - blood, Hypercholesterolemia - complications, Injections, Intravenous, Liver - metabolism, Male, Management. Various non-drug treatments. Langerhans islet grafts, Medical sciences, messenger RNA, metabolism, plasmids, Rabbits, RNA Interference, RNA, Small Interfering - administration & dosage, RNA, Small Interfering - metabolism, rodents, Time Factors, Transfection