Details

Autor(en) / Beteiligte

• Ragsdale, Aaron P
• Nelson, Dominic
• Gravel, Simon
• Kelleher, Jerome

Titel

Lessons Learned from Bugs in Models of Human History

Ist Teil von

• American journal of human genetics, 2020-10, Vol.107 (4), p.583-588

Ort / Verlag

United States: Elsevier

Erscheinungsjahr

2020

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Simulation plays a central role in population genomics studies. Recent years have seen rapid improvements in software efficiency that make it possible to simulate large genomic regions for many individuals sampled from large numbers of populations. As the complexity of the demographic models we study grows, however, there is an ever-increasing opportunity to introduce bugs in their implementation. Here, we describe two errors made in defining population genetic models using the msprime coalescent simulator that have found their way into the published record. We discuss how these errors have affected downstream analyses and give recommendations for software developers and users to reduce the risk of such errors.