Glycoconjugate journal, 2022-02, Vol.39 (1), p.27-38
2022
Details
- Autor(en) / Beteiligte
- Titel
- Novel insights on GM1 and Parkinson's disease: A critical review
- Ist Teil von
- Glycoconjugate journal, 2022-02, Vol.39 (1), p.27-38
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2022
- Link zum Volltext
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- GM1 is a crucial component of neuronal membrane residing both in the soma and nerve terminals. As reported in Parkinson’s disease patients, the reduction of GM1 determines the failure of fundamental functional processes leading to cumulative cell distress up to neuron death. This review reports on the role of GM1 in the pathogenesis of the disease, illustrating the current data available but also hypotheses on the additional mechanisms in which GM1 could be involved and which require further study. In the manuscript we discuss these points trying to explain the role of diminished content of brain GM1, particularly in the nigro-striatal system, in Parkinson’s disease etiology and progression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0282-0080eISSN: 1573-4986DOI: 10.1007/s10719-021-10019-7Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8979868
- Format
- –
- Schlagworte
- Biochemistry, Biomedical and Life Sciences, Brain - metabolism, Cell death, Comprehensive Review, Comprehensive Review Article, Etiology, G(M1) Ganglioside - metabolism, Humans, Life Sciences, Movement disorders, Neostriatum, Nerve endings, Neurodegenerative diseases, Neurons - metabolism, Parkinson Disease - metabolism, Parkinson Disease - pathology, Parkinson's disease, Pathology, The Glycobiology of Parkinson’s disease