Details

Autor(en) / Beteiligte

• Karayama, Masato
• Inui, Naoki
• Inoue, Yusuke
• Yoshimura, Katsuhiro
• Mori, Kazutaka
• Hozumi, Hironao
• Suzuki, Yuzo
• Furuhashi, Kazuki
• Fujisawa, Tomoyuki
• Enomoto, Noriyuki
• Nakamura, Yutaro
• Asada, Kazuhiro
• Uto, Tomohiro
• Fujii, Masato
• Matsui, Takashi
• Matsuura, Shun
• Hashimoto, Dai
• Toyoshima, Mikio
• Kusagaya, Hideki
• Matsuda, Hiroyuki
• Inami, Nao
• Kaida, Yusuke
• Niwa, Mitsuru
• Ito, Yasuhiro
• Suda, Takafumi

Titel

Increased serum cholesterol and long-chain fatty acid levels are associated with the efficacy of nivolumab in patients with non-small cell lung cancer

Ist Teil von

• Cancer Immunology, Immunotherapy, 2022-01, Vol.71 (1), p.203-217

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2022

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Background Lipids have immunomodulatory functions and the potential to affect cancer immunity. Methods The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated in 148 patients with non-small cell lung cancer who received nivolumab. Results When each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol ( P < 0.001), high-density lipoprotein (HDL)-cholesterol ( P  = 0.014), total cholesterol ( P  = 0.007), lauric acid ( P  = 0.015), myristic acid ( P  = 0.022), myristoleic acid ( P  = 0.035), stearic acid ( P  = 0.028), linoleic acid ( P  = 0.005), arachidic acid ( P  = 0.027), eicosadienoic acid ( P  = 0.017), dihomo-γ-linolenic acid ( P  = 0.036), and behenic acid levels ( P  = 0.032) were associated with longer PFS independent of programmed death ligand 1 (PD-L1) expression. Meanwhile, increased LDL-cholesterol ( P < 0.001), HDL-cholesterol ( P  = 0.009), total cholesterol ( P  = 0.036), linoleic acid ( P  = 0.014), and lignoceric acid levels ( P  = 0.028) were associated with longer OS independent of PD-L1 expression. When multiple lipids were evaluated simultaneously, LDL-cholesterol ( P  = 0.003), HDL-cholesterol ( P  = 0.036), and lauric acid ( P  = 0.036) were independently predictive of PFS, and LDL-cholesterol ( P  = 0.008) and HDL-cholesterol ( P  = 0.031) were predictive of OS. ORR was not associated with any serum lipid. Conclusions Based on the association of prolonged survival in patients with increased serum cholesterol and long-chain fatty acid levels, serum lipid levels may be useful for predicting the efficacy of immune checkpoint inhibitor therapy.