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Attenuation of half sulfur mustard gas-induced acute lung injury in rats
Journal of applied toxicology, 2006-03, Vol.26 (2), p.126-131
McClintock, Shannon D.
Hoesel, Laszlo M.
Das, Salil K.
Till, Gerd O.
Neff, Thomas
Kunkel, Robin G.
Smith, Milton G.
Ward, Peter A.
2006
Details
Autor(en) / Beteiligte
McClintock, Shannon D.
Hoesel, Laszlo M.
Das, Salil K.
Till, Gerd O.
Neff, Thomas
Kunkel, Robin G.
Smith, Milton G.
Ward, Peter A.
Titel
Attenuation of half sulfur mustard gas-induced acute lung injury in rats
Ist Teil von
Journal of applied toxicology, 2006-03, Vol.26 (2), p.126-131
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2006
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
Airway instillation into rats of 2‐chloroethyl ethyl sulfide (CEES), the half molecule of sulfur mustard compound, results in acute lung injury, as measured by the leak of plasma albumin into the lung. Morphologically, early changes in the lung include alveolar hemorrhage and fibrin deposition and the influx of neutrophils. Following lung contact with CEES, progressive accumulation of collagen occurred in the lung, followed by parenchymal collapse. The co‐instillation with CEES of liposomes containing pegylated (PEG)‐catalase (CAT), PEG‐superoxide dismutase (SOD), or the combination, greatly attenuated the development of lung injury. Likewise, the co‐instillation of liposomes containing the reducing agents, N‐acetylcysteine (NAC), glutathione (GSH), or resveratrol (RES), significantly reduced acute lung injury. The combination of complement depletion and airway instillation of liposomes containing anti‐oxidant compounds maximally attenuated CEES‐induced lung injury by nearly 80%. Delayed airway instillation of anti‐oxidant‐containing liposomes (containing NAC or GSH, or the combination) significantly diminished lung injury even when instillation was delayed as long as 1 h after lung exposure to CEES. These data indicate that CEES‐induced injury of rat lungs can be substantially diminished by the presence of reducing agents or anti‐oxidant enzymes delivered via liposomes. Copyright © 2005 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0260-437X
eISSN: 1099-1263
DOI: 10.1002/jat.1115
Titel-ID: cdi_proquest_miscellaneous_19712924
Format
–
Schlagworte
Acute Disease
,
Animals
,
anti-oxidant liposomes
,
Antioxidants - administration & dosage
,
Antioxidants - therapeutic use
,
Biological and medical sciences
,
Catalase - administration & dosage
,
Catalase - therapeutic use
,
CEES
,
Chemical Warfare Agents - poisoning
,
Complement System Proteins - physiology
,
Drug Delivery Systems
,
Enzymes - administration & dosage
,
Enzymes - therapeutic use
,
fibrosis
,
Liposomes
,
Lung - pathology
,
Lung Diseases - chemically induced
,
Lung Diseases - pathology
,
Lung Diseases - prevention & control
,
macrophages
,
Male
,
Medical sciences
,
Mustard Gas - analogs & derivatives
,
Mustard Gas - poisoning
,
neutrophils
,
Rats
,
Rats, Long-Evans
,
Reducing Agents - administration & dosage
,
Reducing Agents - therapeutic use
,
Superoxide Dismutase - administration & dosage
,
Superoxide Dismutase - therapeutic use
,
Toxicology
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