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Circulating leptin and NF-κB activation in peripheral blood mononuclear cells across the menstrual cycle
BioFactors (Oxford), 2016-07, Vol.42 (4), p.376-387
Faustmann, Gernot
Tiran, Beate
Maimari, Theopisti
Kieslinger, Petra
Obermayer-Pietsch, Barbara
Gruber, Hans-Jürgen
Roob, Johannes M.
Winklhofer-Roob, Brigitte M.
2016
Details
Autor(en) / Beteiligte
Faustmann, Gernot
Tiran, Beate
Maimari, Theopisti
Kieslinger, Petra
Obermayer-Pietsch, Barbara
Gruber, Hans-Jürgen
Roob, Johannes M.
Winklhofer-Roob, Brigitte M.
Titel
Circulating leptin and NF-κB activation in peripheral blood mononuclear cells across the menstrual cycle
Ist Teil von
BioFactors (Oxford), 2016-07, Vol.42 (4), p.376-387
Ort / Verlag
Netherlands: Blackwell Publishing Ltd
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Using the menstrual cycle as a model, this study focused on longitudinal changes and associations within a physiological network known to play a role in female fertility, including, as biologically active nodes, NF‐κB, leptin and adiponectin, β‐carotene, adipose tissue, and progesterone. In 28 women, leptin, adiponectin, β‐carotene, and progesterone concentrations, NF‐κB p65 and p50 activation in peripheral blood mononuclear cells (known to possess estrogen, progesterone and leptin receptors), total body fat (TBF) and subcutaneous adipose tissue (SAT) mass were determined at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase. Leptin and adiponectin concentrations were higher, while NF‐κB p65 activation was lower at T3 compared with T1. NF‐κB p65 activation was inversely related to leptin concentrations at T1, T3, and T4. β‐Carotene was inversely related to leptin (T1,T2,T4) and SAT (T1,T3,T4). NF‐κB p50 activation was inversely related to TBF (T4) and SAT (T3,T4), and leptin was positively related to TBF and SAT (T1‐T4). Progesterone was inversely related to leptin (T2,T3), adiponectin (T3), TBF (T3,T4), and SAT (T2,T3,T4). By providing evidence of luteal phase‐specific reduced NF‐κB p65 activation in women under physiological conditions, this study bridges the gap between existing evidence of a Th1‐Th2 immune response shift induced by reduced NF‐κB p65 activation and a Th1‐Th2 shift previously observed at luteal phase. For the first time, inverse regressions suggest inhibitory effects of leptin on NF‐κB p65 activation at luteal phase, along with inhibitory effects of leptin as well as adiponectin on progesterone production in corpus luteum. © 2016 The Authors BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology. 24(4):376–387, 2016
Sprache
Englisch
Identifikatoren
ISSN: 0951-6433
eISSN: 1872-8081
DOI: 10.1002/biof.1281
Titel-ID: cdi_proquest_miscellaneous_1815699050
Format
–
Schlagworte
Adipokines
,
Adipokines - blood
,
Adiposity
,
Adult
,
beta Carotene - blood
,
Beta-carotene
,
Body fat mass
,
Cells, Cultured
,
Female
,
Follicular Phase - blood
,
Humans
,
Leptin - blood
,
Leukocytes, Mononuclear - metabolism
,
Longitudinal Studies
,
Luteal Phase - blood
,
NF-kB
,
NFkB
,
nuclear factor kappa B
,
Nuclear factor κB
,
Progesterone
,
Progesterone - blood
,
Transcription Factor RelA - blood
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