Details

Autor(en) / Beteiligte

• Zhang, Shuo
• Sella, Mauro
• Sianturi, Julinton
• Priegue, Patricia
• Shen, Dacheng
• Seeberger, Peter H.

Titel

Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14

Ist Teil von

• Angewandte Chemie (International ed.), 2021-06, Vol.60 (26), p.14679-14692

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi‐synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way. 30 novel oligosaccharides resembling the capsular polysaccharides related to four major serotypes (2, 3, 9, 14) of Streptococcus suis (S. suis) were synthesized. The conjugation‐ready glycans were used to screen the sera of pigs and rabbits. With a glycan array study, glycan epitopes of lead antigens for the development of semi‐synthetic glycoconjugate vaccines to protect from S. suis serotypes 2 and 9 were identified.