Details

Autor(en) / Beteiligte

• Zhang, Xiaodong
• Chen, Xiaokai
• Song, Jun
• Zhang, Junmin
• Ren, Xiangzhong
• Zhao, Yanli

Titel

Size‐Transformable Nanostructures: From Design to Biomedical Applications

Ist Teil von

• Advanced materials (Weinheim), 2020-12, Vol.32 (48), p.n/a

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable sizes. To overcome this challenge, size‐transformable NSs have emerged as a powerful tool, as they can be manipulated to possess the merits of both types of NSs. Herein, various strategies to construct size‐transformable NSs are summarized, and the recent research progress regarding their biomedical applications, particularly within the fields of cancer and bacterial theranostics, is highlighted. This review will inspire researchers to further develop various methods that can be used to construct size‐transformable NSs for use in novel applications within different fields. Size‐transformable nanostructures that can inherit the merits of both small and large ones are powerful platforms for enhanced disease theranostics with long‐term retention, deep penetration, and rapid clearance. Various strategies to realize the transformation between large and small nanostructures are introduced. The biomedical application potential of this kind of nanostructures is also discussed.