Details

Autor(en) / Beteiligte

• Lindqvist, Isa
• Cunningham, Janet L
• Mulder, Jan
• Feresiadou, Amalia
• Rostami, Elham
• Virhammar, Johan
• Kumlien, Eva

Titel

Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid

Ist Teil von

• European journal of neurology, 2023-10, Vol.30 (10), p.3142-3148

Ort / Verlag

England: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• COVID-19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID-19 infection, with no previous neurological disease, are decsribed. Analysis of cerebrospinal fluid from the cases using indirect immunohistochemistry. Antibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus. Our results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID-19 associated myoclonus.