Details

Autor(en) / Beteiligte

• Kerkhoven, Eduard J

Titel

Advances in constraint-based models: methods for improved predictive power based on resource allocation constraints

Ist Teil von

• Current opinion in microbiology, 2022-08, Vol.68, p.102168-102168, Article 102168

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The concept of metabolic models with resource allocation constraints has been around for over a decade and has clear advantages even when implementation is relatively rudimentary. Nonetheless, the number of organisms for which such a model is reconstructed is low. Various approaches exist, from coarse-grained consideration of enzyme usage to fine-grained description of protein translation. These approaches are reviewed here, with a particular focus on user-friendly solutions that can introduce resource allocation constraints to metabolic models of any organism. The availability of kcat data is a major hurdle, where recent advances might help to fill in the numerous gaps that exist for this data, especially for nonmodel organisms.