Details

Autor(en) / Beteiligte

• Zhang, Qian
• Bastard, Paul
• Bolze, Alexandre
• Jouanguy, Emmanuelle
• Zhang, Shen-Ying
• Cobat, Aurélie
• Notarangelo, Luigi D.
• Su, Helen C.
• Abel, Laurent
• Casanova, Jean-Laurent

Titel

Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation

Ist Teil von

• Med (New York, N.Y. : Online), 2020-12, Vol.1 (1), p.14-20

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases. The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.