Details

Autor(en) / Beteiligte

• Sisowath, Christin
• Strömberg, Johan
• Mårtensson, Andreas
• Msellem, Mwinyi
• Obondo, Christine
• Björkman, Anders
• Gil, José P.

Titel

In Vivo Selection of Plasmodium falciparum pfmdr1 86N Coding Alleles by Artemether-Lumefantrine (Coartem)

Ist Teil von

• The Journal of infectious diseases, 2005-03, Vol.191 (6), p.1014-1017

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2005

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Artemisinin derivative–based combination therapy is expected to suppress the development of Plasmodium falciparum drug resistance in Africa. We have performed an artemether-lumefantrine (Coartem; Novartis) follow-up clinical trial in Zanzibar, in which pfcrt K76T and pfmdr1 N86Y frequencies were determined before drug administration and in all recurrent parasites during a follow-up period of 42 days. A significant increase in pfmdr1 86N was observed after exposure to the drug. This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings