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Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
Ist Teil von
Nature genetics, 1996-01, Vol.12 (1), p.31-37
Ort / Verlag
London: Nature Publishing Group
Erscheinungsjahr
1996
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases.